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Gene Engineering Services

Animal Cell Gene Editing

We provide high-efficiency, customizable gene editing services for animal cells, enabling targeted knockout, knock-in, and point mutation modifications in mammalian cell lines. These services are applicable for diverse applications, including cell function studies, disease mechanism research, drug screening, and biopharmaceutical development.

From experimental design and editing component preparation to cell transfection, subsequent clone selection, and validation analysis, we offer a one-stop integrated workflow. Tailored editing strategies are provided based on different cell types, helping you rapidly establish stable edited cell lines and accelerate your research progress.

Service Description

  • Gene Knockout (KO)

    Introduces targeted double-strand DNA breaks in cells to generate deletions or frameshift mutations in the target gene, resulting in loss of gene function. Commonly used for studying gene function or validating drug targets.

  • Gene Knock-in (KI)

    Precisely inserts exogenous sequences at specific loci via homology-directed repair (HDR), such as reporter genes (e.g., GFP) or regulatory elements, enabling targeted labeling and tracking.

  • Point Mutation

    Introduces single or multiple base changes at specific positions to model genetic disease mutations or functional amino acid alterations. Suitable for protein activity studies, mutation effect evaluation, and other precise functional assays.

  • Targeted Editing & Complex Mutation Design

    Provides high-efficiency design of editing strategies, guide RNA selection, and vector construction. Supports integration of multiple editing requirements (e.g., dual-site editing) across various cell types.

 

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Service Workflow
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Consultation and project planning
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Cell condition testing
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Design of editing tools/vectors
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Cell transfection
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Cell pool PCR validation
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Antibiotic selection and single-cell isolation
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Genotype analysis and functional validation
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Data reporting and cell delivery
Sample/Specification Requirements
  • Information on the target gene (including mutation sites, inserted sequences, and editing regions)
  • Source of the cell line and basic culture conditions (e.g., whether serum-free medium is required)
  • Specification of any expression elements or co-transfection fragments, if needed
  • If using a user-provided vector, provide the complete sequence and handling instructions
Shipping Specifications / Acceptance Criteria
  • Cell Line Delivery: Single-clone stable cell line or mixed population (de本地位址 (網址) on customer requirements)
  • Validation Items:
    • – PCR-based genotyping analysis
    • – Sanger sequencing to confirm mutation sites
    • – Antibody staining / Western blot (if protein expression verification is required)
Note: This service is not intended for clinical diagnostics, therapeutic use, or any other medical applications.