A true tumor microenvironment is composed of many different cell types within an organ, including tumor cells, stromal cells, immune cells, pericytes, endothelial cells, and the extracellular matrix (ECM). Culturing these cells in 3D allows them to acquire tissue-like characteristics. Although only tens of micrometers in size, these 3D structures retain the complexity of tissues, creating an environment that closely mimics the in vivo situation.

CellBall Biomedical establishes 3D cell-based drug screening models using next-generation tumor cell lines within an ECM-mimicking environment. This provides researchers with conditions that closely resemble the true tumor microenvironment, yielding more accurate and reliable drug screening results, saving valuable time, and accelerating the progress of experimental development.

New drugs may cause toxicity or damage to various organs and tissues, and such toxic effects can be detected early using corresponding 2D cell-based drug screening models. Before clinical trials or market approval, new drugs must undergo a series of preclinical toxicity assessments to provide safety information.

CellBall Biomedical’s professional team, leveraging years of expertise, customizes drug screening programs according to clients’ research needs and objectives. This includes the design of screening criteria, reagent selection, and experimental planning, as well as professional data analysis to interpret results in detail and generate comprehensive reports, supporting further research and drug efficacy evaluation.

We provide technical services in microbial genetic engineering, focusing on plasmid construction, microbial genome editing, and transformation procedures. Depending on the microbial species and research objectives, we design and execute strategies such as gene introduction, homologous recombination, and targeted editing to support clients’ development needs in protein expression, metabolic engineering, and functional analysis.

We provide high-efficiency, customizable gene editing services for animal cells, enabling targeted knockout, knock-in, and point mutation modifications in mammalian cell lines. These services are applicable for diverse applications, including cell function studies, disease mechanism research, drug screening, and biopharmaceutical development.

From experimental design and editing component preparation to cell transfection, subsequent clone selection, and validation analysis, we offer a one-stop integrated workflow. Tailored editing strategies are provided based on different cell types, helping you rapidly establish stable edited cell lines and accelerate your research progress.

We provide professional and customized services for generating gene-edited mouse models, assisting clients with various genetic engineering approaches such as knockout (KO), knock-in (KI), and point mutations of target genes. From experimental design and gene editing to the delivery of mature mice, we employ a fully integrated, one-stop workflow to maximize editing efficiency and success rate. This service is suitable for applications including disease mechanism studies, drug development, and functional gene investigations.

This service provides recombinant protein expression and purification using yeast as the host, suitable for applications such as research protein production, antigen development, and activity validation. The yeast system combines the protein modification capabilities of eukaryotes with high-efficiency cultivation, making it an ideal choice between bacterial and mammalian cell systems. Protein production can be carried out using systems such as Pichia pastoris or Saccharomyces cerevisiae, depending on your requirements.

This service provides recombinant protein expression and purification using mammalian cells as hosts, suitable for producing proteins that require proper folding, glycosylation, or other mammalian-specific post-translational modifications. It assists clients in obtaining high-quality, biologically active target proteins, suitable for downstream functional studies, antibody production, or product development.

We provide a one-stop integrated service for importing experimental mice, assisting domestic researchers and biotech companies in quickly obtaining required foreign mouse resources. From initial strain search and technical consultation to subsequent mouse reproduction and genotyping, we offer professional support throughout the process to ensure smooth experimental progress.